Structural Biology on Molecular Mechanism of Low-Affinity Protein-Protein Interactions on the Cell Membrane

Protein-protein interactions are essential in diverse cellular processes including signal transduction. It is not uncommon for protein-protein the transmembrane signaling to exhibit low binding affinities with a dissociation constant μM range or higher. Presumably, membrane proteins can selectively bind their partners via low-affinity because they only diffuse laterally plane and interact within limited space on surface membrane. This review focuses crystallographic studies cell-surface receptors intramembrane proteases that perform mediated by interactions.